11 Amazing Benefits of Calamine Lotion – How to Use It the Right Way

Bid farewell to various skin issues with this incredible and moisturizing lotion!

Medically Reviewed by Dr. Jeanny Kim, ND
By Ravi Teja Tadimalla, Professional Certificate In Food, Nutrition & Health

From treating sunburns, itchiness, and skin infections to wounds, the benefits of calamine lotion are immense. It is a mix of ferric oxide and zinc oxide supported by other important ingredients such as calcium hydroxide and phenol. This lotion has featured on the Model List of Essential Medicines (21st edition) released by the WHO (World Health Organization) (1).

Calamine lotion is cheap, effective, safe, and easy to use. However, the latest studies suggest that it may not effectively treat severe infections like shingles, chickenpox, etc. (2).This article discusses all these aspects in detail besides explaining how to use this lotion safely and the potential risks to be wary of. Keep reading.

What Is Calamine Lotion? How Does It Work?

A bottle of calamine lotion


Calamine lotion is a topical drug formulation that treats itching and irritation. It helps reduce insect bites and plant (e.g., poison ivy/oak) allergies (3), (4).

This lotion has a base of zinc oxide and iron oxide that gives it a reddish-pink tint. These minerals, particularly zinc, provide great relief from itching (pruritus) (5), (6).

Zinc oxide has anti-inflammatory properties, which further add to the benefits of calamine lotion.

What Are The Benefits Of Calamine Lotion?


Calamine lotion contains zinc, which is crucial for the maintenance and functioning of the skin. It may aid in relieving skin irritation, plant allergies, and infections.

1. May Treat Plant (Poison Ivy/Oak) Allergy

A woman with poision ivy rash


The rash caused by poison ivy, poison sumac, and poison oak is an allergic reaction to their sap. The clear or pale yellow sap escapes from damaged areas of the dead or alive plant and gets absorbed into your skin almost immediately (7), (8).

The affected areas start itching and turn red, swollen, and blistered. In severe cases, patients develop oozing or weeping sores (7).

To manage the rash, wash the affected area with cold water and soap within 30 minutes of contact. Cover the blisters with generous amounts of calamine lotion. The zinc oxide in this lotion relieves local inflammation, dryness, itching, and soreness (6), (7), (8).

If the infection persists and gets severe, your doctor can prescribe a stronger topical cream or oral steroids.

2. May Help Manage Acne

Studies have shown that topical and oral supplementation of zinc reduces the symptoms of acne vulgaris. Topical zinc could reduce the growth of Propionibacterium acnes strains due to its sebum-reducing and anti-inflammatory effects (6).

Calamine lotion is a zinc-rich formulation. It controls the production of histamines, compounds that flare inflammation. In a 2010 study, subjects who were treated with oral antibiotics in combination with calamine showed satisfactory results (9).

However, there is no evidence that shows a direct positive effect of calamine on acne (6).

3. May Heal Chickenpox Symptoms

A woman covered with chickenpox blisters


Most of the treatment for chickenpox focuses on relieving the itching of the pox blisters and preventing broken blisters (as a result of scratching) from getting infected (11).

Cool baths with uncooked oatmeal followed by topical application of calamine lotion can help reduce the itching and dryness (10), (11).

However, no studies have evaluated the effect of calamine lotion on itching associated with chickenpox (2).

4. Treats Diaper Rashes In Babies

This lotion has proven to soothe skin irritation and mild rashes. It is thus added to creams or ointments that are applied to diaper rashes in babies and infants. Calamine works by keeping the skin free of moisture and protects chafed and sensitive skin (12).

Change wet and soiled diapers promptly. Clean the diaper area and allow it to dry. Apply calamine lotion or cream liberally and as often as necessary with each diaper change. Follow this routine, especially at bedtime and when the diaper has been on for an extended period (12).

Some infants have sensitive skin or other underlying skin conditions. It is recommended that you consult a pediatrician before applying calamine or any medication on the baby. Also, if the rash persists even after a week, report it to the doctor (12).

5. Helps Manage Insect Bites, Hives, And Scabies

A woman scratching an insect bite on her shoulder


Working with bees, aphids, and bugs involve frequent insect bites that may lead to hives, scabies, and infection. Applying ice packs and calamine lotion can be an immediate solution to relieve itching and inflammation (13), (14).

Calamine may also offer temporary relief from spider bites. Scabies and stings/bites from fleas, mites, and chiggers can also be managed by applying it topically. But if pain, swelling, and redness persist, consult a healthcare provider (13), (15), (16).

6. May Provide Relief From Sunburns

Sunburns are often accompanied by acute itching and redness. Applying calamine lotion can relieve these primary symptoms. It may also moisturize and soothe the affected dry areas (8).

However, if the small blisters break, apply an antibiotic cream and not a moisturizing lotion like calamine. In case the rash gets worse, seek medical help (17).

7. Relieves Itching During Pregnancy

A pregnant woman scratching her itchy belly


Around 1-8% of pregnant women experience uncontrollable itching in specific areas of their body, which may worsen at night. Hormonal changes may cause acute pruritus (itching). These changes may also impact pre-existing skin diseases or cause new pregnancy-induced skin conditions (18), (19).

Ideally, patients should be on bed-rest and a low-fat diet. Topical medications like calamine lotion, cooling agents, and emollients can be given under medical guidance. Any oral medication may have a direct effect on the newborn or the fetus, so only mild antihistamine drugs or steroids may be administered. They should only be given to augment the topical medication (18), (19).

8. May Help Manage Eczema And Psoriasis

The zinc oxide in calamine lotion plays a critical role in managing eczema and psoriasis. It is a potent anti-inflammatory agent that manages itching, dryness, and irritation caused by these skin conditions. Applying this lotion at bedtime has shown positive effects on itching (6), (20), (21).

Topically applied zinc oxide formulations also have intense antioxidant and antibacterial effects. They may restore the skin barrier function, lower free radical damage, and eliminate bacterial colonies in the affected areas (6).

However, there are no scientific trials that establish the direct effect of calamine lotion on psoriasis and eczema.

9. May Reduce Viral Warts And Shingles

Viruses cause most of warts you see on your skin and around nails. These viruses usually include human Papilloma Virus(HPV), Herpes Simplex Virus (HSV), Herpes Zoster, and Human Immunodeficiency Virus (HIV). Depending on the type of virus, warts can appear on your hands, feet, back, face, or genitals (6), (22).

The zinc derivatives in calamine formulation may eradicate warts and shingles, according to recent studies. Though research has not proven the action of calamine lotion in these cases yet, it is commonly used as a general relief medication (6), (22).

It is safe to consult your doctor before using any medication, especially if your genitals are affected.

10. May Lower Fungal Infection Symptoms

Fungal pathogens often cause skin infections characterized by itching. Athlete’s foot, jock itch, ringworm, Candida intertrigo, toenail fungal infection, and carbuncles are a few examples of such infections (23).

Soothing creams like calamine lotion or emollients can be applied to the infected area under medical supervision. Most fungal and yeast infections lead to secondary infections, especially when they are not treated completely (24).

Your healthcare provider may prescribe stronger oral and topical antifungal medication in such cases.

11. May Accelerate Wound And Ulcer Healing

The mineral zinc is vital for wound healing. It is critical for skin regeneration. Studies show that topical supplementation of zinc oxide is more effective than the oral regimen. Zinc oxide formulations can heal diabetic foot ulcers, burns, wounds, and blisters (6), (25).

They also have antimicrobial properties and, thus, prevent microbial infection of open wounds. Therefore, calamine and insoluble zinc oxide have been listed as mild antiseptics, astringents, and protective agents in superficial wound care(25).

With all these benefits, calamine lotion can be considered as a first-aid staple. Here’s how you use it.

How To Apply Calamine Lotion Safely

Note: Calamine lotion is for external use only. Do not swallow it. Do not use it on the eyes or on inside the mouth, nose, genital, or anal areas. Please proceed with medical consent only. Do not self-medicate.

  1. Before using, shake the bottle of calamine lotion well.
  2. Moisten a sterile cotton pad with the lotion.
  3. Gently dab the cotton pad on the affected area(s).
  4. Allow the lotion to dry on the skin. It may turn pale pink.
  5. If you are using calamine ointment, apply enough product to cover the affected area(s) and rub in gently.
  6. Close the lid and store the bottle away from your clothes. Calamine lotion can stain fabric when it dries.
  7. Store the medicine container at room temperature, away from heat, moisture, and direct light.
  8. Keep out of the reach of children.

Note: Wash your hands before and after using calamine. Put on hand gloves and a nose mask if you are working on large, infected, and oozing areas.

Is calamine entirely safe for topical use? Can it be used on adults as well as children? Check out the next section for answers.

What Are The Side Effects Of Calamine Lotion?

There are almost no proven adverse effects associated with the (excess) use of calamine lotion (3).

But, in rare cases, you may experience:

  • Irritation
  • Swelling around the calamine-treated area
  • Hives on the tongue, throat, or face

If such symptoms persist, stop using calamine lotion immediately. Consult a healthcare provider, report your observations, and try an alternative medication (3).

Moreover, there is insufficient information about the safety of calamine for pregnant and nursing women and children/infants. Seek medical help before using it.

The benefits of calamine lotion are numerous. The lotion is a mixture of ferric oxide, zinc oxide, calcium hydroxide, and phenol. This lotion is topically applied to relieve plant allergy, acne, chickenpox symptoms, diaper rash, insect bites, hives, scabies, and sunburns. Calamine lotion can also help treat skin itching during pregnancy, eczema, psoriasis, shingles, viral warts, and fungal infection symptoms. It also accelerates wound and ulcer healing. However, this lotion may trigger irritation, swelling, and hives in some people. Though this could be rare, caution is advised. Should these side effects persist, consult your healthcare provider without delay.

Frequently Asked Questions

Can calamine lotion remove dark spots?

Possibly. Anecdotal evidence suggests that repeated application of calamine lotion may help lighten dark spots. However, the results are not significant.

Can you sleep with calamine lotion on?

Yes. You can apply calamine lotion overnight to soothe your skin and manage acne. But when it comes to sensitive skin, it is best to avoid keeping it on for a long time.

Is calamine lotion good for wrinkles?

While anecdotal evidence suggests that calamine lotion may help reduce fine lines and wrinkles, scientific studies on this matter are still lacking.


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Ravi Teja Tadimalla is an editor and a published author. He has been in the digital media field for over... more

Dr. Jeanny Kim

“No one should settle for a life of illness. I believe that, with time and personal effort, anyone can achieve... more