The 10 Best Digestive Enzyme Supplements Of 2021

Written by Priyanka Sadhukhan , Nutritionist, CDE, Reviewer & Writer
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Digestive enzymes help break down food, so our body can absorb the nutrients. These nutrients are further broken into small molecules and released into the blood. However, sometimes, our body doesn’t produce enough digestive enzymes, and this may slow down digestion (1).

This can gradually lead to conditions like cystic fibrosis, chronic pancreatitis (inflammation of the pancreas), and pancreatic cancer (1). Fortunately, you can replenish these enzymes with the assistance of over-the-counter digestive enzyme supplements.

They are easily available in drugstores, health stores, or online. People who cannot produce enough digestive enzymes can use these supplements. In this article, we will be focusing on the 10 best digestive enzyme supplements, their benefits, and their side effects.

TOP 10 PRODUCTSCheck Price
Zenwise Health Daily Digestive Enzymes With Prebiotics & Probiotics
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Now Super Enzymes Tablets
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Dr. Tobias Digestive Enzymes
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Mav Nutrition Digestive Enzymes
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Dr. Matthew Digestive Enzymes
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Naturenetics DigestWise Powerful Digestive Enzymes
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Rainbow Light Advanced Enzyme System (Dietary Supplement)
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Source Naturals Essential Enzymes
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Divine Bounty Digestive Enzymes
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Vimerson Health Digestive Enzymes
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Note: Before consuming these supplements, it is recommended that you consult your doctor and test your digestive function.

Top 10 Digestive Enzyme Supplements Of 2019

1. Zenwise Health Daily Digestive Enzymes With Prebiotics & Probiotics

Zenwise Health’s Daily Digestive Enzymes contains a blend of plant-based enzymes that aid healthy digestion. These supplements ensure proper intake of vital nutrients that help in strengthening your digestive system. They are specially formulated to help with bloating, constipation, indigestion, and gas.

The prebiotic and probiotic blend supports digestion and enables your body to absorb all the nutrients from meals. It also contains a 10 plant-based enzyme blend with Amylase, Glucoamylase, Lipase, Protease, Invertase, Maltase, Cellulase, Bromelain, Lactase, and Papain. The turmeric and green papaya in them help reduce stomach bloating and any other discomfort.

Directions: Take one tablet immediately before every meal (three times a day).

  • Reduce inflammation
  • Reduce the frequency of diarrhea
  • Keep your gut healthy in the long run
  • Improve bowel
  • Restore blood flow
  • Contain shellfish

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2. Now Super Enzymes Tablets

This award-winning (Vitamin Retailer Magazine – Vity Awards) product is formulated with bromelain, ox bile, pancreatin, and papain. These are the best digestive enzymes as the ingredients break down fat, carbs, and proteins and optimize nutrient availability for a healthy digestive system.

Directions: Take one tablet with a meal.

  • Free of dairy, soy, and egg
  • Help with gallbladder issues
  • Keep your skin healthy
  • Relieve stomach aches
  • Initially, you may experience a burning sensation in your heart.

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3. Dr. Tobias Digestive Enzymes

Dr. Tobias Digestive Enzymes are formulated with 18 plant-based enzymes that help process difficult-to-digest foods like gluten, carbs, protein, sugar, fat, lactose, and fiber. They strengthen your digestive system and prevent digestive Problems such as post-meal gas.

Directions: Take one tablet with a meal.

  • Formulated with the finest ingredients
  • Approved by the FDA and GMP
  • Improve bowel movements
  • Enable you to eat anything without any discomfort
  • Contain dairy, soy, and wheat.

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4. Mav Nutrition Digestive Enzymes

Mav Nutrition Digestive is the best Enzyme that contains 3 essential types of probiotics for digestive health. Probiotics help in maintaining the healthy bacteria in the intestines for smooth digestive function. The best part about this product is that it does not contain artificial preservatives.

The formula contains protease, acidophilus, bromelain, lipase, and lactase. These constituents help in breaking down food. If you are experiencing diarrhea and indigestion and frequent occurrences of gas, these supplements will help purify your digestive system. They will help your system to digest proteins, fats, and carbohydrates without any discomfort. They relieve constipation and bloating.

Directions: Take one tablet, 20-30 minutes before or with the meal.

  • Break down the most difficult proteins, fats, and carbohydrates
  • Boost energy levels
  • Help regulate the digestive hormone secretion
  • Help you stay active and healthy
  • Not gluten-friendly
  • Cause bloating the first few times

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5. Dr. Matthew Digestive Enzymes

Dr.Matthew’s #1 Digestive Enzyme supplements are formulated using 19 plant-based enzymes, including amylase, bromelain, lipase, lactase, alpha-galactosidase, and pectinase.

This multi-enzyme blend is 6 times more potent for lactose digestion, 5 times more effective in digesting complex carbs, and 2 times more potent for proteins, fats, and gluten.

They reduce stomach bloating, gas, heartburn, diarrhea, indigestion, intestinal cramps, abdominal pain, belching, nausea, and fatigue. They help conditions like irritable bowel syndrome, constipation, acid reflux, and leaky gut. They help your body extract more nutrients from the food you eat so that you have more energy and vitality.

Directions: Take one tablet immediately before every meal.

  • Certified by NSF and FDA
  • Free of chemicals
  • Non-GMO
  • Reduce inflammation
  • Contain aspergillopepsin and DPP IV for gluten digestion
  • Help you digest most of your food in the first 30 minutes
  • Relieve food intolerances
  • Vegan


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6. Naturenetics DigestWise Powerful Digestive Enzymes

Naturenetics DigestWise Powerful Digestive Enzymes Supplements provide you with multiple enzymes like amylase, protease, pectinase, cellulase, alpha-galactosidase, amyloglucosidase, lipase, acid-stable protease, lactase, and hemicellulase that are carefully selected for their ability to work with a large pH range.

The broad spectrum of microbial-derived enzymes helps break down complex proteins, fats, sugars, carbohydrates, fiber, and dairy products. Due to this, you may feel less sluggish and more active. The enzymes are sourced from the USA, Denmark, Japan, Finland, and Belgium and are prepared in a state-of-the-art manufacturing facility in Oregon.

DigestWise is free of soy, dairy, gluten, wheat, sugar, yeast, and corn. These enzyme supplements ensure that you get all the potent nutrients from the food you eat. The supplements claim to give you great results within 90 days.

Directions: Take one tablet immediately before every meal.

  • Break down fats and oils
  • Perfect for sensitive stomachs
  • Provide comfort after every meal
  • Package includes 90 capsules


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7. Rainbow Light Advanced Enzyme System (Dietary Supplement)

Rainbow Light Advanced Enzyme System contains 10 plant-based enzymes like

  • Amylase to break down complex carbohydrates, sugars, and starches.
  • Lopase to break down complex fats found in nuts, oils, meats, and dairy products.
  • Protease to break down the proteins in eggs, cheese, and meat.
  • Invertase to break down sucrose.
  • Cellulase to break down the fiber in vegetables and grains.
  • Lactase to break down lactose.

These enzymes support a balanced digestive system. The formula contains enzyme-rich foods like green papaya, apple pectin, peppermint, fennel, and ginger to promote digestive comfort and reduce constipation, bloating, and gas. These supplements are the best enzymes for bloating

Directions: Take one tablet immediately before every meal.

  • Boost nutrient absorption
  • Free of soy, yeast, and dairy
  • Do not contain egg, fish, or shellfish
  • No artificial additives
  • Soothe stressed stomach
  • Rapid-release formula
  • Not approved by the FDA

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8. Source Naturals Essential Enzymes

Source Naturals Essential Enzymes have a bio-aligned formula that contains multiple enzymes. These supplements support and balance the 12 metabolic systems in your body for optimal functioning.

They aim to help your system to absorb nutrients that work at the cellular level. This will bring balance among all the interdependent systems in your body. The enzymes present in these supplements break down complex proteins, fats, carbohydrates, fibers, and dairy sugar.

Directions: Take one tablet immediately before every meal. Do not exceed 6 capsules per day.

  • Non-GMO verified ingredient
  • Undergo multiple quality-testing
  • Free of gluten, soy, wheat, yeast, dairy, sugar, and preservatives
  • Detailed ingredients list
  • A little expensive

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9. Divine Bounty Digestive Enzymes

Divine Bounty Digestive Enzymes are designed to replenish and fortify your body’s enzyme levels to promote healthy digestion and 100% vital nutrients absorption. They are formulated with pre and probiotics enzymes for healthy digestion of fats, oils, proteins, carbohydrates, and dairy. With this, the lost energy from poor digestion is regained.

With regular use, these enzyme supplements support a healthy digestive system with bacterial balance. They contain galactosidase and beta-glucanase, which help break down beans, grains, and vegetables, and invertase and glucoamylase for digestion of sugars.

Directions: Take one tablet immediately before every meal.

  • Free of soy, gluten, and artificial preservatives
  • Fortified with 6 essential vitamins
  • Approved by the FDA
  • Contain high-quality ingredients
  • Unpleasant odor

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10. Vimerson Health Digestive Enzymes

Vimerson Health Digestive Enzymes support overall gastrointestinal health. They contain a powerful blend of natural enzymes and probiotics for balancing the digestive system.

The formula includes protease to digest proteins and debris in the blood, bromelain to improve muscle health, papain, lipase, lactase to break down food and proteins into amino acids and amino blocks, and lactobacillus that supports healthy bowel movements.

Directions: Take one capsule 30 minutes before lunch, and one capsule 30 minutes before dinner.

  • Promote optimal nutrient absorption
  • Reduce post-meal discomfort
  • Prevent diarrhea
  • Contain natural digestive enzymes and easily absorbable ingredients
  • Take time to work.

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These are the top 10 digestive enzyme supplements. The digestive system is also known as the ‘second brain.’ This because a healthy digestive system leads to a healthy body. Here are the benefits of digestive enzyme supplements. Take a look.

Benefits Of Digestive Enzyme Supplements

1. Help Digest Food Better

Digestive enzyme supplements are plant-based and microbe-derived enzymes that help break down proteins, carbohydrates, and lipids (2). They keep your gastrointestinal system healthy and help in the management of multiple digestive disorders (3).

2. Boost Nutrient Absorption

Digestive enzyme supplements enhance nutrient absorption by breaking down proteins, fats, and carbohydrates from the food you eat. The nutrients are transported from the small intestine into the bloodstream to increase your energy levels.

The enzymes ensure that molecules like fats, carbs, and proteins are broken into smaller molecules so that they can get absorbed easily. This improves your immunity as well.

3. Reduce Bloating And Gas

Certain enzymes like alpha-galactosidase and cellulase break down complex carbohydrates like beans, vegetables, and grains. As these foods are difficult to digest, when the enzymes help break them down, conditions like gas, bloating and stomach pain are reduced.

Other sets of enzymes like lipase and lactase help break down fiber-rich veggies, dairy products, and legumes. These foods commonly cause gas and bloating. If you experience any discomfort after consuming these foods, digestive enzymes supplements may help.

4. Help Digest Dairy

Almost 68% of the world’s population is lactose intolerant (4). Many people lack the essential enzyme, lactase. Lactase helps digest lactose, a common type of sugar found in milk, ice cream, cheese, and other dairy products. Digestive enzyme supplements that contain lactase can help reduce symptoms of poor dairy digestion.

5. Reduce Gastrointestinal Disorders

According to a research project conducted on Functional Gastrointestinal Disorders at the Atlanta Center For Holistic And Integrative Medicine, 98 adults with Functional Gastrointestinal Disorder were asked to take probiotics and digestive enzymes for eight weeks. The results showed that the participants had improved gastrointestinal quality of life scores and underwent significant weight loss (5).

6. Reduce Acid Reflux

Acid reflux, also known as gastroesophageal reflux disease (GERD), is a digestive disorder that affects the lower esophageal sphincter. In other words, the stomach’s contents travel back into the esophagus, causing heartburn. Along with changes in lifestyle and diet, digestive enzyme supplements can help reverse the disorder. These supplements empty your stomach to reduce the reflux of stomach contents.

7. May Help Manage Irritable Bowel Disease

Irritable Bowel Syndrome is a disorder that affects the large intestine. It causes bloating gas and constipation. Since digestive enzyme supplements help break down complex carbs, proteins, and fats, they can help reduce the symptoms of IBS (Irritable Bowel Syndromes). These supplements include essential components like lactobacilli and probiotics that help with indigestion (6).

8. May Give You Clearer Skin

A healthy digestive system is connected to various functions of your body. That includes your skin too! If your body is not absorbing essential nutrients, the effect can be seen on your skin. If there is a lot of inflammation in your system, you may experience breakouts and acne.

Now that you are aware of the benefits, let’s look at things you need to know before consuming digestive enzyme supplements.

What You Need To Be Aware Of Before Taking Digestive Enzyme Supplements

  • Digestive enzyme supplements only work when there is food in your system. Taking them on an empty stomach will not work.
  • The idea behind these supplements is that they help your system cope with irregular digestion. Once your body heals, it continues to secrete the essential digestive enzymes naturally. But, it takes up to six months for your digestive system to start functioning normally. Hence, taking these supplements regularly may help.
  • Different brands suggest different intakes. Some digestive supplements are to be taken with a meal, while some are recommended to be taken before eating. Check the directions on the label clearly before using it.

Digestive enzyme supplements have a flip side. Find out what it is in the next section.

Are There Any Side Effects?

Are There Any Side Effects


Since digestives enzyme supplements are sourced from plants, the side effects are negligible. But, in some cases, they can cause mild allergic reactions to a specific enzyme, resulting in continuous diarrhea, nausea, or stomach cramps.

Read the label thoroughly to check if you are allergic to any of the ingredients. If you are experiencing inflammation or heartburn, consult a doctor immediately.


If you are experiencing gas, bloating, and indigestion after every meal, these digestive enzyme supplements may work wonders. However, the symptoms differ from person to person. Therefore, before using these supplements, consult a doctor to avoid any complications. Although there are many benefits of these supplements, research shows limited results. Hence, exercise caution.

Let us know how these products worked for you by leaving a comment below.

Frequently Asked Questions

Do digestive enzyme supplements really work?

Yes. But, to get complete benefits, it is suggested that you use these supplements every day for a month.

Can digestive enzyme supplements help with weight loss?

It depends on your body type. However, healthy digestion leads to a healthy body. You do not have to worry about your weight as your body will receive all the essential nutrients at the right time.

How long does it take for digestive enzyme supplements to work?

Since these supplements do not need much time to be absorbed by your body, they work within 5 to 20 minutes. But it takes up to 30-40 days to regulate the natural digestion process.

Recommended Articles

  1. Gut reaction: A limited role for digestive enzyme supplements” Harvard Health Publishing, Harvard Medical School.
  2. Digestive Enzyme Supplementation in Gastrointestinal Diseases” Current Drug Metabolism, US National Library of Medicine, National Institutes of Health.
  3. The role of enzyme supplementation in digestive disorders.” Alternative Medicine Review, US National Library of Medicine, National Institutes of Health.
  4. Lactose Intolerance” National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health.
  5. Restoring Digestive Health” Doctor of Nursing Practice (DNP) Translational and Clinical Research Projects, Georgia College.
  6. The Role of Bacteria, Probiotics, and Diet in Irritable Bowel Syndrome” Foods, US National Library of Medicine, National Institutes of Health.

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Priyanka is a nutritionist and a Certified Diabetes Educator. She has over 8 years of experience in nutrition and dietetics with a strong research background. She is passionate about science and how it can be applied to one’s daily lifestyle. According to her, food is the best medicine, and proper nutrition is key to achieving good health. She has also written a book on PCOS and its management for doctors and patients. When she is not working, she loves spending quality time with family and friends. She loves creating innovative, healthy recipes and endorses healthier alternatives to junk foods to promote good health.