The 7 Best Microbiome Skin Care Products To Try In 2023

Benefit from ingredients that work for, and not against, your skin's natural microbiome.

By Shiboli ChakrabortiShiboli Chakraborti, Certified Skin Care Coach  • 
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Most of you must be already aware that many skincare products might cause harm to a lot of microorganisms present on your skin. Therefore, switching to the best microbiome skincare products is essential. Microbiome-friendly skincare products have natural bacteria that help maintain your skin’s overall health and keep its natural glow intact. In addition, these products effectively help reduce skin concerns like acne, fine lines, wrinkles, and even dryness. So, let’s check out the best microbiome skin care products now. Keep scrolling!

Top Picks
Best Overall : La Roche-Posay Toleriane Ultra
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Best For All Skin Types: Mother Dirt AO+ Restorative Mist
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Best Vegan Formula: Audrey & Young Cica Biome Cleansing Balm
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Best Lightweight Formula: I Like Cica Biome Serum
Price on Amazon
Best For Dry Skin: Cure Code Neuromide Ampoule
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Best Clinically-Tested: Madeca Derma Microbiome Ampoule
Price on Amazon
Best For Sun-Damaged Skin: Codex Beauty Labs Brightening Face Serum
Price on Amazon

The 7 Best Microbiome Skin Care Products In 2023

1. Best Overall: La Roche-Posay Toleriane Ultra

La Roche-Posay Toleriane Ultra Image: La Roche-posay

The shea butter-infused La Roche-Posay Toleriane Ultra repairs sensitive skin with a soothing touch. The comforting creamy adds moisture to the skin and makes it feel soft and supple. Use it to provide long-lasting comfort to dry and sensitive skin. This facial moisturizer boasts a limited number of ingredients with the tolerance of sensitive skin in mind. It is infused with thermal spring water and instantly hydrates your skin. This minimalist formula-based cream comes without preservatives, fragrances, is allergy-tested, and comes in an airtight package, which keeps outside contamination away. Check this video to learn more about the product.

Key Ingredients: Shea Butter, Prebiotic thermal water, and Neurosensine

Skin Type: Sensitive, Combination, and Normal


  • Paraben-free
  • Preservative-free
  • Oil-free
  • Fragrance-free
  • Non-drying
  • Alcohol-free
  • Non-comedogenic
  • Dermatologically-tested


  • Expensive
protip_icon Trivia
The key ingredient in La Roche-Posay products, the thermal spring water, is obtained from La Roche Posay, which is a small village in Western France. The brand is also named after the place.
Price at the time of publication: $30.99

2. Best For All Skin Types: Mother Dirt AO+ Restorative Mist

The Mother Dirt AO+ Restorative Mist is enriched with ammonia-oxidizing bacteria. This mist protects and maintains healthy skin by restoring and balancing the microbiome. It improves skin tone, smoothness, and clarity in just 30 days. This is first of its kind product that uses active probiotics for radiant, healthier-looking skin. The live AOB interacts with the elements naturally found on your skin and in sweat to produce two potent by-products: nitrite and nitric oxide. Since it contains live bacteria, it is recommended to keep the bottle in the refrigerator. Take a look at this video to get more information on the product.

Key Ingredients: Ammonia oxidizing bacteria

Skin Type: All


  • Soothing
  • Clinically-proven
  • Cruelty-free
  • Fragrance-free
  • Vegan
  • Suitable for all skin types


  • May cause breakouts
Price at the time of publication: $69

3. Best Vegan Formula: Audrey & Young Cica Biome Cleansing Balm

The Cica Biome Cleansing Balm by Audrey & Young soothes skin irritation and is designed to improve the dermal barrier to promote skin health. Its melting sherbet texture and biome ingredients offer deep cleansing with a 3-layer texture soothing effect. The balm has an anti-sebum complex that is effective for pores and sebum control. It gently cleanses the skin and can clear waterproof makeup with ease to give you a clear, soft, and smoothe skin.

Key Ingredient: Cica Biome and Centella Asiatica

Skin Type: Dry and Sensitive


  • Gentle
  • Paraben-free
  • Silicon-free
  • Sulfate-free
  • Hypoallergenic
  • Vegan


  • May cause irritation
  • Greasy
protip_icon Trivia
Cica is an ancient plant found in Asia and Southern Africa. It is believed that Asian tigers used to roll in the herb for quick healing of wounds.
Price at the time of publication: $28

4. Best Lightweight Formula: I Like Cica Biome Serum

The hyaluronic acid-enriched I Like Cica Biome Serum is a face hydrating serum that gently repairs and improves skin texture quickly. It balances skin oil levels by improving the fundamental skin environment. The serum contains natural plant extract, which soothes your skin, and strengthens its barrier. It is a lightweight product that gets quickly absorbed into the skin and leaves no oily residue.

Key Ingredients: Cica Biome, Green Calming Complex, and Aquaxyl

Skin Type: Dry and Sensitive skin


  • Quick absorbing
  • Vegan



Price at the time of publication: $33.9

5. Best For Dry Skin: Cure Code Neuromide Ampoule

The skin-soothing complex ingredients in the Cure Code Neuromide Ampoule calms your skin and improves its texture. It is enriched with the goodness of neuromide, which combats skin dryness and repairs ultra-sensitive skin. The skin care product uses tri-biotics which works like wonder to protect the healthy skin microbiome. It can increase skin elasticity and glow. This product contains panthenol that moisturizes the skin to relieve dryness.

Key Ingredients: Neuromide 4000ppm, Aquatide, and Panthenol,

Skin Type: Sensitive and Dry


  • Natural ingredients
  • Silicon free
  • Paraben-free
  • Artificial fragrance-free
  • Artificial colorant-free
  • PEG-free
  • Mineral oil-free



Price at the time of publication: $32

6. Best Clinically-Tested: Madeca Derma Microbiome Ampoule

The Madeca Derma Microbiome Ampoule is made from skin-friendly bacteria and keeps signs of aging away. It strengthens the skin barrier to protect it against environmental threats and works quickly to improve skin texture within 30 days of use. This product is formulated with advanced biotechnology and consists of 70,0000ppm of hyaluronic acid and 125,000ppm of biome ball. Its biome ball splicing technology hydrates the skin from the deep to maintain its hydration level. The ampoule contains five major structural components that include fibrillin, elastin, skin-collagen, hyaluronic acid, and ceramide.

Key Ingredients: Hyaluronic acid, Fibrillin, Elastin, Ceramide, and Skin-collagen

Skin Type: Dry


  • Hydrates
  • Anti-aging
  • Value for money



Price at the time of publication: $59.99

7. Best For Sun-Damaged Skin: Codex Beauty Labs Brightening Face Serum

The Codex Beauty Labs Brightening Face Serum has an enriching formula to rejuvenate dull and damaged skin. This product helps the skin fight against harmful pollutants present in the air. It is clinically tested and is known to re-densify the skin. The hydrating formula of the serum offers a soothing effect to the sunburned skin. Those dealing with uneven skin tone will benefit from the daily use of this serum. It is recommended for skin firming and brightening. This plant-powered serum features hibiscus extract that fades fine lines. It also contains cherimoya that supports, smoothens, calms, and rebalances your skin.

Key Ingredients: Antucomplex, Cherimoya, Hibiscus, and Entadine

Skin Type: All


  • Suitable for daily use
  • Clinically-tested


  • Might cause splotches
  • Expensive
Price at the time of publication: $75

If you are still wondering about the meaning of skin microbiome, fret not. Read the next section to understand this natural phenomenon in detail.

What Is Skin Microbiome?

The skin microbiome is a community of naturally occurring good bacteria on the skin surface that maintains the skin barrier and protects against other harmful bacteria. The skin feels and looks radiant, soft, supple, and healthy when the microbiome is balanced.

Microbiome-friendly products have gained immense popularity in recent days and are a worthy addition to your beauty stash. However, you need to consider a few facts while making the final choice.

Here is the guide to some important elements to consider while buying microbiome skin care products.

How To Choose The Best Microbiome Skin Care Products

  • Consider Skin’s Need: There is no such thing as one-size-fits-all when it comes to beauty products. Every skin has different requirements and thus needs the products accordingly. Make sure to consider your skin’s needs and type before initiating a search for these products. Once you have decided on the requirement, it will be easy to purchase the microbiome skin care product.
  • Ingredients: The market is flooded with microbiome-friendly products, but not all live up to the hype. Before finalizing any product, check the list of ingredients to make sure you are not allergic to any of them. Choose products that contain microbiome-friendly ingredients like probiotics, postbiotics, oats, and niacinamide. These ingredients maintain a healthy skin microbiome.
  • Lightweight And Quick Absorbing: Microbiome products are mainly used to minimize skin issues, including acne, excess sebum, etc. Hence, investing in the option that quickly penetrates the skin and leaves no greasy feel behind is mandatory.
  • Budget: Since microbiome skin care products contain live bacteria, these are a bit expensive. Furthermore, the price depends on various factors, including the types of ingredients, brand, and benefits it offers. The products with a big brand name and high-priced tags seem fascinating, but not all of them guarantee the best outcome. Therefore, you need to decide the budget first, check the ingredients, and then invest. Keep in mind that skincare products are all about their ingredients and advantages and the brand name and price tags have nothing to do with it.

Harsh chemical-based skin care products may strip off the good microorganisms present on the skin. Microbiome-friendly skin care products help balance the natural bacteria and maintain skin health. In addition, they help reduce the early signs of aging, like fine lines around the mouth and wrinkles around the eyes. Microbiome skin care products are vegan, paraben-free, and hydrating. Go through the product reviews and buying guide to grab the product that suits your skin type. Do a patch test if you have extremely sensitive skin.

Frequently Asked Questions

How to use microbiome skin care products?

Microbiome skin care products can be used directly on freshly washed skin. Gently massage it on the skin in a circular motion to ensure deep penetration. If you are new to the skin care regime, it is better to read the instructions given on the package.

Is there any harm in using microbiome products?

No. These products are safe to use and do not contain harsh ingredients.

How often can I use microbiome products?

These products are for daily use. However, it is wise to read the instructions before using any product.

Who should not use microbiome products?

People with extremely sensitive skin should not use microbiome products. Check the ingredients list and do not blindly go for the product because it contains microbiome.

How do I rebuild my skin microbiome?

Besides using microbiome products, avoid harsh cleansers that remove defensive components from your skin and make it appear rough. Also, remain fit and eat a healthy diet to keep your gut and skin microbiome intact.

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