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11 Exclusive Health Benefits Of Olive Leaf Extract

Medically reviewed by Lucas Aoun, Naturopathic doctor
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11 Exclusive Health Benefits Of Olive Leaf Extract Hyderabd040-395603080 May 31, 2019

It is not mere coincidence that the olive tree is a symbol of peace, wisdom, and health. Olive fruit and olive oil are known for their health benefits. The latest addition to this bandwagon is olive leaves.

The olive leaf is a treasure chest of medical applications. Its alcoholic and water-based extracts have anti-atherosclerotic, anti-inflammatory, antioxidant, antimicrobial, anti-allergic properties.

This article gives you an idea of all the aspects of olive leaf extract. We will discuss what it does, why it does, and how to make/take it in this read. Brace yourself and start scrolling!

What Is Olive Leaf Extract? What Is Unique About Olive Leaves?

Olives and olive oil are reservoirs of health benefits. But the leaves of olive trees are no less

! Olive leaf extract is extracted from olive leaves by soaking them in alcohol or water for an extended period.

The goodness of olive leaves gets extracted into the solvent in the form of biochemicals. Oleuropein, hydroxytyrosol, tyrosol, etc. are a few active molecules that are responsible for the therapeutic importance of these leaves (1).

Olive leaves are traditionally known to prevent cardiac disease and hypertension. They can protect membranes from lipid oxidation and inflammation. The extract can also improve lipid metabolism, exhibit antiviral properties, reduce cancer risk, etc. (2).

This is why olive leaf tea is a classic in the Mediterranean cuisine and tribes.

The following sections will fill you in with details about the benefits, recipes, and risks of this Greek wonder.

Scroll down!

What Are The Benefits Of Olive Leaf Extract?

1. Might Lower The Risk Of Hypertension And Cardiovascular Diseases (CVDs)

Olive leaves contain a phenolic compound called oleuropein. It makes up about 6-9% of the dry matter of olive leaves. The higher the oleuropein concentration, the greater the antioxidant property (3).

Administering olive leaf extract to experimental mouse models showed hypotensive effects (3).

It might lower systolic and diastolic blood pressure individuals with hypertension (4).

This oleuropein-rich extract improves vascular function by reducing the stiffness in arteries. These observations highlight the cardioprotective and anti-inflammatory nature of olive leaf extract.

Consuming it daily might lower atherosclerosis, stroke, heart attack, disease, blood pressure (hypertension), and other cardiovascular diseases (3), (4).

2. Might Combat HIV Infection

HIV infection triggers the expression of genes controlling cell death (apoptosis), stress, and DNA damage. Using olive leaf extract can reverse several such changes caused by HIV infection (5).

Olive leaf extract treatment can restore different cell signaling pathways in infected cells. It can also inhibit cell-to-cell transmission of HIV, which is a critical step in the life cycle of a virus (5).

This might happen because oleuropein interacts with an HIV-1 protein, gp41. Disabling this protein can prevent the spread of infection of HIV into host cells (6).

3. Eliminates Candida And Other Fungi

Hydroxytyrosol, tyrosol, oleuropein, and derivatives have potent antifungal properties. These compounds can kill fungi, molds, and yeast, especially the species that affect your respiratory and GI (gastrointestinal) tract (7).

A study was conducted on lab-cultured Candida albicans with aqueous olive leaf extracts. Within 24 hours of treatment, about 15% of Candida were destroyed. Olive leaf extract was toxic to Candida albicans and Candida neoformans (7).

Processed extracts of olive leaf can thus replace synthetic antimicrobial compounds as preservatives. However, this extract was ineffective against certain yeast species (8).

4. Treats Skin Diseases, Wounds, And Acne

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Oleuropein is an anti-inflammatory and antioxidant agent. It stimulates collagen fiber synthesis and inhibits pro-inflammatory cell infiltration. This extract also scavenges free radicals in the affected area to speed up wound healing (9).

Applying olive leaf extract two to three times a day can reduce acne and pimples significantly. Several topical homeopathic formulations include this extract. It can treat cold sores, eczema, burning, itching, and eruptions on your skin (10).

This vulnerary activity is attributed to the biochemical composition of the olive leaves. Luteolin and 7-O-glucoside were found to be the active principles. Other compounds responsible for these activities include oleuropein, other secoiridoids, and flavonoids (11).

5. Might Aid Weight Loss In Obese Individuals

Olive leaf extract exerts anti-obesogenic effects at a molecular level, according to animal studies. It can regulate the expression of genes involved in fat accumulation in your body. Olive leaf-supplemented diet also reduced the food intake by 26% in treated mice (12).

This visceral fat cut-down might lead to reduced plasma levels of free fatty acids (FFA). This means lesser lipid oxidation in the liver. Ultimately, this leads to a drop in plasma triglyceride (particularly, LDL) levels (12).

The olive leaf biochemicals – hydroxytyrosol, luteolin, and caffeic acid – can aid healthy weight loss. Incorporating it into your routine can also help in effective weight management (12).

6. Reduces Inflammation And Can Help Treat Inflammatory Diseases

Olive leaf phytochemicals like hydroxytyrosol, tyrosol, oleuropein, and oleocanthal show anti-inflammatory and antioxidant effects. The olive leaf extract treatment lowered the pro-inflammatory chemical messengers (like TNF-α) in rat models (13).

Another study demonstrated the effect of olive leaf extract on injured rabbits. The rabbits were supplemented with drinking water and olive leaf extract (500 mg/kg/day). Healing in rabbits treated with this water was quicker than in their untreated counterparts. This proves the anti-arthritic effects of olive leaf compounds (14).

Olive leaf extracts contain oleuropein, oleuropeoside, and other polyphenols. These chemicals can help to manage inflammatory diseases like colitis, inflammatory bowel disease (IBD), rheumatoid arthritis, and osteoarthritis (14).

7. Possesses Antiproliferative Properties

Olive leaf extract has higher diversity in biochemical composition than extra virgin olive oil. Cancer cell models show that olive leaf polyphenols protect against DNA damage caused by free radicals (15). This means reduced cancer risk.

The leaf extract was found to be effective against prostate and breast cancers. It also impedes the proliferation of pancreas, colorectal, leukemia, and lung cancer cell lines (15).

Here’s a mind-blowing fact. The olive leaf polyphenols like oleuropein can discriminate between cancer and normal cells. They trigger apoptosis (programmed cell death) only in cancer cells and not normal cells (15). Talk of targeted therapy!

8. Stimulates New Hair Growth

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In mouse studies, topical application of olive leaf extract induced significant hair growth. The oleuropein in this extract could interact with dermal papilla cells to stimulate hair growth (16).

The dermal papilla cells are responsible for the growth and differentiation of epithelial cells. They instruct the epithelial cells to proliferate, move upward, and divide to form the hair shaft, root, sheath, etc. (16).

Administering oleuropein (0.4 mg/mouse/day) also improved the surrounding skin vasculature. It upregulated the gene expression of KGF, HGF, and VEGF (growth factors). These factors enhance the blood circulation, nurturing the hair follicles in the skin (16).

However, there are physiological differences between mouse and human skin/hair. Hence, these studies might need appropriate auxiliary evidence (16).

9. Protects The Brain And Prevents Cognitive Decline

Olive leaf extract was given to lead-poisoned rats in a study. It reduced neuronal and capillary injury and improved brain function. This extract reduced damage to organelles and the matrix around the capillaries in the cerebral cortex of the rat brain (17).

Olive leaf extract reduces oxidative damage. It boosts the levels of antioxidant enzymes like superoxide dismutase, catalase, and alkaline phosphatase (17).

Oral administration of olive leaf extract may alter brain water content and blood-brain barrier permeability. It blocks pro-inflammatory compounds, lipid peroxidation, and oxidative stress-induced cognitive decline (18).

10. Might Treat Periodontitis And Improve Oral Health

Thanks to the composition of olive leaves, they possess antimicrobial activity against a horde of oral pathogens. The leaf extract inhibited the growth of Streptococcus oralis, Candida albicans, Escherichia coli, Porphyromonas gingivalis, Fusobacterium nucleatum, and Parvimonas micra (19).

Olive leaf extract is often used with other herbal ingredients in dental remedies. They include clove leaf, thyme, grapefruit seed extract, chamomile flower, green tea leaves, Eucalyptus leaf, cinnamon bark, and several essential oils (20).

This herbal remedy is considered safe for humans and animals.

You can find this extract in lozenges, dental chews, candies, beverages, toothpaste, oral gels, and whitening molds (20).

11. Manages Hypoglycemia (High Blood Sugar) And Diabetes

Olive leaf extract is well known as a traditional anti-diabetic and antihyperglycemic herbal drug. One obvious reason behind these effects is the antioxidant activity of olive leaf polyphenols (21).

Olive leaf extract may influence glucose-induced insulin release. It could also increase the uptake of glucose by the surrounding tissues (21).

In clinical trials, subjects treated with olive leaf extract exhibited significantly lower HbA1c and fasting plasma insulin levels. HbA1c is glycated hemoglobin, which is formed when free glucose molecules bind to hemoglobin molecules. HbA1c is indicative of hyperglycemia (22).

By lowering HbA1c levels and improving insulin sensitivity, olive leaf extract can effectively manage the blood glucose homeostasis in humans (22).

This exhaustive list of benefits proves the leaves of olive are as healthy as the fruit.

What is in these leaves that make(s) their extract a potential health staple?

Scroll down to discover!

Biochemical Composition Of Olive Leaves

The chemical composition of olive leaves depends on several conditions – the origin, climate, moisture content, the proportion of branches on the tree, storage conditions, and soil quality (21).

Generally, most of the therapeutic benefits of olive leaves are attributed to their polyphenolic content.

There are five groups of phenolic compounds mainly present in olive leaves (21):

  1. Oleuropeosides: Oleuropein and verbascoside
  1. Flavones: Luteolin-7-glucoside, apigenin-7-glucoside, diosmetin-7-glucoside, luteolin, and diosmetin
  1. Flavonols: Rutin
  1. Flavan-3-ols: Catechin
  1. Substituted phenols: Tyrosol, hydroxytyrosol, vanillin, vanillic acid, and caffeic acid

The most abundant compound in olive leaves is oleuropein. It is followed by hydroxytyrosol, luteolin, apigenin, and verbascoside (21).

The total polyphenol content of olive leaves was determined to be 2,058 mg GAE (gallic acid equivalent). Hence, these leaves have exceptionally high free radical-scavenging (antioxidant) properties (21).

Let’s get to the obvious question.

How To Make Olive Leaf Extract

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Well, the simplest way of making and taking olive leaf extract is brewing its tea.

All you need to do is:

  • Brew the fresh or dried leaves with some water.
  • Let it steep for 5-7 minutes.
  • Mix in a little sweetener because the tea can be really bitter.
  • Drink up!

If you want to give this bitter tea a miss, here’s what you could try.

DIY: Olive Leaf Tincture

What You Need
  • Fresh or dried olive leaves
  • Vodka (40-45%)
  • Clean mason jar
  • Knife/food processor

Let’s Make It!

  1. Wash the leaves well (if they are fresh ones).
  1. Chop them finely or shred in a food processor and place them in a glass jar.
  1. Cover the chopped leaves with vodka.
  1. For fresh leaves, the ratio of leaves to vodka is 1:2 or 3, i.e., if you’re using 8oz. of leaves, you’d need 16-24 oz. of vodka.
  1. If you’re using dried leaves, the ratio is 1:5.
  1. Stir well. Seal the mason jar, and let it sit in a dark place for about 2-6 weeks.
  1. Shake it once in a while and make sure the leaves are all covered by vodka. Add more if you need to.
  1. Strain the liquid into a dark-colored (amber) dropper bottle.And your tincture is ready!

Do not use it on open/bleeding wounds. Consult your doctor to know about its safety if you are pregnant or lactating.

Alternatively, you can purchase olive leaf extract capsules here.

Dosage

  • If you are using the olive leaf tincture, add 1-2 drops of it to a glass of water and consume. Consult your physician for a customized dose regimen.
  • If you are taking the capsules, you may take one capsule thrice a day. Total intake should range between 500 mg to 1000 mg per day. However, your physician knows the best.

We recommend medical guidance while using olive leaf supplements. This is because there are a few documented adverse effects of this herbal medicine.

Possible Side Effects And Risks Of Olive Leaves

High doses of olive leaf extract might interfere with the activity of antioxidant enzymes. In short, excess of olive leaf extract can become pro-oxidative (23).

It may nullify the effect of in-house enzymes like superoxide dismutase and catalase in eliminating the free radicals (23).

Wild olive leaf extract can interact with several classes of drugs. The leaf polyphenols may alter the permeability and transport of these drugs in the bloodstream (24).

As a result, there could be an increase in the blood levels of these drugs when taken simultaneously with the wild olive leaf extract, thus indicating potential adverse effects that need to be studied (24).

There is inconclusive evidence about the adverse effects of olive leaf extract. Hence, it is best for pregnant and lactating mothers to abstain from using this herbal medicine.

In Conclusion…

Olive leaf extract is one of the medieval remedies for herpes, HIV, skin, hair, brain, inflammatory diseases, and overall well-being. Make a small batch of olive leaf extract with the recipe we shared here.

You can also try the olive leaf capsule to experience the above-discussed benefits. Remember, always consult your doctor about the safety and dosage for you.

Tell us how this herbal medicine worked for you. Give us your feedback, suggestions, and comments in the box below.

References

  1. Oleuropein in Olive and its Pharmacological Effects” Scientia Pharmaceutica.
  2. Olive Leaf Extracts Act as Modulators of the…” Endocrine, Metabolic & Immune Disorders – Drug Targets, US National Library of Medicine.
  3. Prolonged Oral Administration of Oleuropein Might Protect…” Iranian Journal of Pharmaceutical Research, US National Library of Medicine.
  4. Impact of phenolic-rich olive leaf extract on blood…” European Journal of Nutrition, US National Library of Medicine.
  5. Anti-HIV activity of olive leaf extract (OLE) and…” Biomedical And Biophysical Research Communications, US National Library of Medicine.
  6. Computational study of bindings of olive leaf…” FEBS Letters, US National Library of Medicine.
  7. Evaluation of the antifungal activity of olive…” Current Medical Mycology, US National Library of Medicine.
  8. Antifungal activity of olive leaf (Olea Europaea L.)…” Annals of Microbiology, Academia.
  9. Evaluation of Effect of Oleuropein on Skin Wound…” Cell Journal, US National Library of Medicine.
  10. OLIVE LEAF ACNE REMEDY- topical skin relief liquid” Vitality Works, Inc., DailyMed, US National Library of Medicine.
  11. Main Benefits and Applicability of Plant…” Cosmetics, MDPI.
  12. Olive Leaf Extract Attenuates Obesity in High-Fat…” Evidence-based Complementary and Alternative Medicine, US National Library of Medicine.
  13. Mechanisms of olive leaf extract-ameliorated rat…” Phytotherapy Research, US National Library of Medicine.
  14. Therapeutic Effects of Olive and Its Derivatives on…” Nutrients, US National Library of Medicine.
  15. Evidence to Support the Anti-Cancer Effect…” Nutrients, US National Library of Medicine.
  16. Topical Application of Oleuropein Induces Anagen…” PLoS ONE, US National Library of Medicine.
  17. Olive leaf extract inhibits lead poisoning-induced…” Neural Regeneration Research, US National Library of Medicine.
  18. The neuroprotective effect of olive leaf extract is related…” Phytomedicine, Elsevier, Academia.
  19. High-Level Antimicrobial Efficacy of Representative…” BioMed Research International, US National Library of Medicine.
  20. Herbal Remedies for the Treatment of Periodontal…” Recent Patents on Drug Delivery & Formulation, Academia.
  21. Olive tree (Olea europaea) leaves…” Special Article, Nutrition Reviews.
  22. Olive leaf extract as a hypoglycemic agent in both human…” Journal of Medicinal Food, US National Library of Medicine.
  23. Effects of high dose olive leaf extract on the hemodynamic…” Journal of the Serbia Chemical Society.
  24. Potential Herb-Drug Pharmacokinetic Interactions between…” Planta Medica, US National Library of Medicine.