6 Benefits Of Polyhydroxy Acids For Skin | Types & How To Use

Protect yourself from various skin woes and get a radiant look with this effective solution.

Medically reviewed by Dr Ashok GundDr Ashok Gund, MBBS, CSD
By Arshiya SyedaArshiya Syeda  • 

Polyhydroxy acids (PHAs) are mild chemical exfoliants that nourish your delicate skin. Polyhydroxy acids for skin are popular among those with sensitive and breakout-prone skin. They are mild and help exfoliate the skin without causing irritation and damage.

Any skin care routine is incomplete without exfoliation. And PHAs are best for those who cannot tolerate other chemical exfoliants like alpha-hydroxy acids. They help remove the dead skin and help improve your skin texture.

However, people still have a double mind regarding the safety of polyhydroxy acids. Are you wondering the same? We can help. This article discusses everything you need to know about polyhydroxy acids for skin, their benefits, and how to use them. Keep reading.

What Are Polyhydroxy Acids (PHAs)?

Polyhydroxy acids (PHAs) are a new generation of alpha-hydroxy acids (AHAs) that have been used since the 1970s for their skin-smoothing, exfoliating, and anti-aging effects. The most common PHAs are gluconolactone, galactose, and lactobionic acid.

While PHAs work similarly to AHAs, they do not cause any sensory irritation responses as some AHAs do. Products containing PHAs are known to be compatible with Caucasian, African American, Hispanic, and Asian skin (1).

Take a look at the various benefits of PHAs below.

6 Benefits Of PHAs

Woman with dull skin may benefit from a PHA serum

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PHAs are a very gentle category of acids that can be used by anyone irrespective of their skin type. Here are some of their best-known benefits:

1. Exfoliate Gently

PHAs are very mild on the skin. These acids gently slough off the dead skin cells and help revive dull-looking skin. They can improve skin texture and offer anti-aging benefits without causing any harm (2).

2. Fight Against Free Radicals

Some PHAs are known to have antioxidant properties that help your skin fight against free radicals. Free radicals break your skin’s collagen down and lead to wrinkles, dryness, and sensitivity. By acting as free radical scavengers, these acids protect your skin from damage and delay the signs of aging (3).

3. May Improve The Efficacy Of Other Ingredients

PHAs, such as gluconolactone or lactobionic acid, can work well in combination with retinoli  XA form of retinoid derived from Vitamin A that possesses anti-aging, acne-clearing, and skin-rejuvenating properties. to make your skin smoother and plumper. Combining them with hydroquinonei  XA skin-lightening chemical that bleaches your skin by reducing the number of melanocytes (cells that make melanin) in your body. can also make anti-aging products more effective (1). However, more human trials are needed to support these claims.

4. Acts As A Humectant

PHAs are also known for their humectant and moisturizing properties. They enhance the skin’s stratum corneum (outermost skin layer) barrier function. They keep moisture sealed in your skin and keep it hydrated for long (1).

5. May Protect Against Sun Damage

Some PHAs, such as gluconolactone, may have the potential to protect skin against UV radiation. Preliminary research in this area shows promising results (2). However, further research is needed to prove these claims.

6. Suitable For Individuals With Specific Skin Conditions

Even though exfoliation is an essential part of skincare, many people can’t enjoy its benefits due to preexisting skin conditions like eczema or rosaceai  XAn inflammatory skin condition that typically affects the face and causes redness and frequently tiny, red bumps that are filled with pus. . However, PHAs are so mild and nourishing that they are compatible even with chemically sensitive skin (1).

AHAs and BHAs are also popular exfoliants like PHAs. But how are they different from each other?

AHAs Vs. BHAs Vs. PHAs

Hand with a bottle of serum and more bottles in the background

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1. Alpha-Hydroxy Acids (AHAs)

AHAs are organic acids used as superficial peeling agents for many years. Glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid are among the most commonly used AHAs. They are water-soluble and exfoliate the skin through a process known as apoptosis.

Exfoliating with AHAs makes the skin more sensitive to sun damage. AHAs may also cause redness, burning, and swelling (3). AHAs might also have anti-aging properties, though this claim is yet to be proven.

protip_icon Trivia
Dr. Yu and Dr. Van Scott discovered the beneficial effects of AHAs on human skin in the early 1970s.

2. Beta-Hydroxy Acids (BHAs)

BHAs are oil-soluble acids often used in cosmetic preparations as exfoliants. They work on the skin’s surface and penetrate the skin cells to slough dead skin cells and dissolve excess sebum. They also decongest pores. Salicylic acid is the most commonly used BHA.

BHAs are best suited for those with oily and combination skin types. They also work great for those prone to blackheads, whiteheads, enlarged pores, and breakouts as they can easily penetrate blocked pores. BHAs are also thought to reduce the appearance of fine lines and wrinkles.

BHAs are generally considered gentler than AHAs and don’t irritate the skin upon use. They are recommended to be used with a sunscreen (4).

3. Polyhydroxy Acids (PHAs)

PHAs are considered the gentlest among the three classes of exfoliants. They have larger molecular structures compared to AHAs and cannot penetrate the skin too deeply. They also work slower than AHAs, and, therefore, are not as hard on the skin. Their mildness makes them suitable for all skin types, including skin that is chemically sensitive.

PHAs work by exfoliating dead skin cells and excess debris on the skin surface, and expose the firmer and suppler skin underneath. They also moisturize as they exfoliate, giving your skin a softer, smoother finish. They are also believed to promote cell renewal and rejuvenation.

PHAs are the gentlest of the lot. But are they totally safe? Or do they have any adverse effects?

Do PHAs Have Any Side Effects?

Woman experiences breakouts due to PHAs

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PHAs are considered safe for most skin types and generally do not result in side effects. However, if you have extremely sensitive skin that tends to break out at the slightest pretext, you should exercise caution while using PHAs. Ultra-sensitive skin can react to any new skin care product. Hence, it is important to start slowly.

One probable side effect of using any exfoliant is purging. When you add a new product to your skin care regime, your skin might react by breaking out. The removal of the dead skin cells and sebum on the surface of the skin may cause the trapped sebum under the debris to rise to the surface and cause a breakout.

However, this doesn’t have to be a cause for concern. Purging is a beneficial process that helps clear the skin. Don’t panic if PHAs cause your skin to purge. Just continue to use the product. Your skin should clear up on its own in about 4 to 6 weeks, and you will eventually get smoother skin.

Using PHAs the right way can give you great results. Here’s how.

How To Use PHAs For Skin

Woman takes a few drops of PHA serum to apply on her face

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Using an exfoliant with PHAs helps gently rub the dead skin cells off the skin and restores the skin’s natural beauty. Here is the right way to use these acids:

  1. Remove all traces of makeup and wash your face with fresh water and a mild facial cleanser. Pat dry.
  2. Dampen a cotton pad with some toner and apply it all over your face and neck, avoiding the lips and the delicate areas around your eyes.
  3. Take a small amount of the gel or cream on your fingertips and apply it all over your face. If your product is in a liquid form, you can apply it with a cotton pad.
  4. Wait for a few seconds and allow it to dry.
  5. Continue with your skin care regime and apply other products in the order you usually follow.

While PHAs are known to be gentle, it is always a good idea to start slow with chemical exfoliants. Begin by testing the product on a small region on your arm or leg and leave it on for a few hours. Discontinue if you experience any allergic reaction or discomfort. But if there is no reaction, you may start using it on your facial skin.

All facial acids can potentially cause side effects when your skin is exposed to the sun. Hence, ensure you always use sunscreen along with PHAs in your daily routine.

Although PHAs are very mild, you should exercise caution when it comes to mixing them with other active ingredients. Keep reading to know more.

What Should You Not Mix With PHAs?

If you read the ingredients lists of commercial exfoliant products, you may see that PHAs are often used with AHAs and BHAs. While oily skin prone to acne is likely to tolerate these three acids, other skin types may react.

Even though PHAs are quite gentle, combining them with other chemical exfoliants can lead to skin irritation. Thus, to be on the safer side, consider using products containing only one type of exfoliating acid. Also, choose products only with PHAs if you have ultra-sensitive skin prone to eczema, dryness, or rosaceai  XAn inflammatory skin condition that typically affects the face and causes redness and frequently tiny, red bumps that are filled with pus. .

Several types of PHAs are used in beauty care products. But which ones suit your skin the best? Let’s find out.

What Types Of PHAs Are The Best?

Woman confused between two bottles of PHA serums

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1. Gluconolactone

Gluconolactone is one of the most popular ingredients in facial products for sensitive skin. It is known for its gentle exfoliating effects. It also serves as a humectant and seals skin moisture. It is known to have antioxidant properties and may even protect your skin from UV damage (2).

2. Lactobionic Acid

Lactobionic acid is an iodized form of lactose that is derived from milk sugars. Anecdotal evidence suggests that it can fight the signs of aging, unclog pores, and even out one’s skin tone. It is also said to prevent the degradation of collagen and keep your skin looking younger. However, more empirical studies are needed to confirm its efficacy as an anti-aging ingredient.

3. Galactose

Galactose is also derived from milk sugars. It is less commonly used than the above two PHAs. It is said to be a gentle exfoliant. It moisturizes your skin while sloughing away the dead skin cells from your skin surface. Anecdotal evidence suggests that galactose may help reduce hyperpigmentation and the appearance of dark spots.

protip_icon Did You Know?
Charles Weissman first coined the term ‘galactose,’ deriving it from the Greek word ‘galaktos,’ meaning milk, and the general suffix of sugar, ‘tose.’

How Often Can You Use PHAs?

PHAs are generally considered gentle enough for daily use on most skin types. However, those with sensitive skin are recommended to use them 2 to 3 times a week. You may gradually start using them daily.

Experiment with different products to find out what works best for you. Serums with PHAs are a popular choice for those who have never used the ingredient before. You can start using them daily once your skin gets used to the acids.

Is It Safe To Use PHAs With Ingredients Like Vitamin C Or Retinol?

Some beauty YouTubers and bloggers believe it is safe to use PHAs in combination with vitamin C or retinoli  XA form of retinoid derived from Vitamin A that possesses anti-aging, acne-clearing, and skin-rejuvenating properties. . A few beauty influencers even recommend using it with retinoli  XA form of retinoid derived from Vitamin A that possesses anti-aging, acne-clearing, and skin-rejuvenating properties. for best results.

However, on the contrary, some beauticians warn against mixing PHAs with retinoli  XA form of retinoid derived from Vitamin A that possesses anti-aging, acne-clearing, and skin-rejuvenating properties. or vitamin C due to potential skin irritation.

There is no scientific evidence to back either of the claims. Hence, run a patch test of these combinations to see how your skin reacts.

Summing It Up

Polyhydroxy acids are newer and gentler versions of alpha-hydroxy acids (AHAs) popular among people with sensitive skin and acne. Their moisturizing and antioxidant properties slow down aging, exfoliate your skin gently and protect your skin from damage, making them the perfect addition to your skincare routine. Make sure you remove all makeup and clean your face before applying polyhydroxy acids to your skin. While polyhydroxy acids for your skin are safe for use and suitable for all skin types, consult a doctor immediately if you develop any adverse reactions.

Frequently Asked Questions

Is polyhydroxy acid good for dry skin?

Yes, polyhydroxy acid is good for dry skin. PHAs act as humectants that attract water and moisturize the skin.

Is hyaluronic acid a polyhydroxy acid?

Hyaluronic acid and polyhydroxy acid are not the same and they have different properties. Hyaluronic acid is naturally produced by your body. Whereas polyhydroxy acid is a chemical exfoliant that helps improve skin elasticity and slows down skin aging.

Is PHA better than BHA?

PHAs are suitable for all skin types, including eczema and rosaceai  XAn inflammatory skin condition that typically affects the face and causes redness and frequently tiny, red bumps that are filled with pus. skin conditions, and are a lot gentler on the skin. Whereas BHAs are suitable for oily and acne-prone skin.

Can PHA be used with niacinamide?

Yes. PHA can be used with niacinamide. However, for optimal results, layer them as separate steps rather than mixing these formulas.

Key Takeaways

  • Polyhydroxy acids (PHAs) are a group of mild and effective chemical exfoliants.
  • They also act as humectants, protect against sun damage, and fight free radicals.
  • Galactose, gluconolactone, and lactobionic acid are the most used PHAs.
  • PHAs can be included in your skin care regime twice or thrice a week.


Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. Read our editorial policy to learn more.

  1. The use of polyhydroxy acids (PHAs) in photoaged skin
  2. A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen
  3. The polyhydroxy acid gluconolactone protects against ultraviolet radiation in an in vitro model of cutaneous photoaging
  4. Beta Hydroxy Acids
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