15 Best Perricone MD Products, As Per An Esthetician (2025)
Create your skincare regime with the right skincare essentials and get the skin of your dreams.
Hillary Clark is a third-generation beauty entrepreneur, celebrity makeup artist, and medical esthetician with 21 years of experience. Her stints as the youngest Beauty Director for Nordstrom and West Coast Beauty Editor for Sephora provided ample opportunities for her to collaborate with some of the most popular names in the beauty industry, such as Dr.
Read full bio of Hillary Clark
Experience: 4 yearsShiboli has a master’s degree in English literature from The English and Foreign Languages University, Hyderabad, and is a certified skincare coach with four years of experience. As a commerce editor, she guides her team members on the best practices to create crisp and authentic content.
Read full bio of Shiboli Chakraborti
Experience: 5 yearsAditi Naskar has a postgraduate degree in English literature from Presidency University, Kolkata, a bachelor’s degree in education from WBUTTEPA, Kolkata, and a diploma in health and wellness. She is an associate commerce editor with 5 years of experience and specializes in reviewing fitness and health products.
Read full bio of Aditi Naskar
Experience: 11 yearsRamona is an editor at StyleCraze with 11 years of experience in writing and editing. She has authored over 200 articles on skin and hair care. She graduated from the University of Calcutta, West Bengal, and did her post-graduation from the University of Kalyani, West Bengal.
Read full bio of Ramona Sinha
Image: StyleCraze Design Team
The best Perricone MD products are an excellent choice if you’re seeking an effective and holistic skincare line to combat the aging of the skin. This company has been established for almost 2 decades and sells a variety of cosmetics, supplements, and advanced skincare products. Clean eating, use of natural products, and sustainability are some of the brand philosophy’s core beliefs, which emphasizes beauty from within Each product from this luxury skincare brand is backed up by publicly available clinical evidence. Because of its transparency and efficacy, Perricone MD has become a cult favorite. Hillary Clark, Medical Esthetician, says, “Dr. Perricone taught me about the connection between inflammation and disease. Some produstc from this brand are still a core part of my skin care ritual today. Reducing inflammation is key to healthy, glowing skin.” We’ve put together a list of 15 of the best Perricone MD products on the market right now. Learn more about them by reading below!
In This Article
Who Is Dr. Perricone?
Dr. Perricone is an assistant clinical professor at the Yale School of Medicine. He treats aging as an “inflammatory disease.” Dr. Perricone believes in the holistic philosophy of healing and wellness. He advocates clean eating to combat the effects of aging on the skin along with the use of natural ingredients in skin care products. He has written many books on aging, wellness, and nutrition. ‘The Wrinkle Cure’ is a best-seller that recommends having a diet rich in omega-3-fatty acids to fight wrinkles and fine lines instead of using invasive or expensive surgical procedures.
What Are Some Of The Main Ingredients Found In Perricone MD Products?
- Hyaluronic acid: Replenishes moisture in the skin as it can hold up to 1,000 times its weight in water, resulting in plump and younger-looking skin.
- Vitamin F: It is found in sardines, argan, pumpkin seed, flaxseed, macadamia seed, chia seed, and rosehip seed oils. It is unsaturated fat that is essential for the structural and functional integrity of the skin.
- DMAE (dimethylaminoethanol): DMAE can stimulate skin cell function to give you healthy skin.
- Acyl-glutathione: This antioxidant captures free radicals that are released due to aging and stress.
- Neuropeptides: This potent ingredient fights the signs of aging like fine lines, sagging skin, wrinkles, dullness, and hyperpigmentation.
- Vitamin C Ester: This derivative or form of vitamin C is safe and effective. It helps in boosting collagen production which, in turn, improves skin elasticity and firmness. This powerful antioxidant protects the skin from aging and brightens it. Hillary Clark says, “This the Gold Standard of Vitamin C – it is both fat and water soluble; so it works deep in the skin, is more stable and gentle. It is expensive but worth it.”
- Phytocannabinoids: This group of antioxidants is derived from the hemp plant. They offer protection from sun damage and aging.
- Vitamin E: It is sourced from various ingredients such as cold-pressed kukui nuts and olives. It provides intense hydration, moisturization, and protection to the skin.
Now that we know all about Perricone MD as a brand, let’s check out all the products that they have to offer in their clinical skincare range.
15 Best Perricone MD Products Available Right Now
1. Best Anti-Aging:Perricone MD High Potency Classics: Face Finishing & Firming Moisturizer
Perricone MD’s Face Finishing & Firming Moisturizer is one of their best-selling moisturizers. It is rich in antioxidants and nourishing nutrients that reduce the appearance of fine lines and wrinkles. It has a velvet rose fragrance and lightweight consistency. It has a rich texture that deeply hydrates the skin to make it visibly smoother and radiant. Hillary Clark says this deeply hydrating and nourishing formula is a must-have. If you are still unsure what to buy, this video review might be useful.
Pros
- Increases skin radiance
- Reduces the appearance of fine lines and wrinkles
- Hydrates the skin
- Smoothens the skin
- Paraben-free
- Sulfate-free
- Vegan
Cons
- Strong fragrance
Pro Tip
Why We Think It's Worth Buying
The extensive 1,469 rave reviews on Amazon prove why we are vouching for this product.
2. Best Hypoallergenic:Perricone MD Hypoallergenic Firming Eye Cream
No products found.
The Perricone MD Hypoallergenic Firming Eye Cream has a rich and creamy formula, but it is non-greasy. Hillary Clark, a Medical Esthetician, recommends this product saying, “I keep this in my kit and use it on all of my clients with extremely sensitive and reactive eyes. You can even layer it on thick as an eye mask.” It gets absorbed instantly to provide deep hydration to the delicate skin around the eyes. It is fragrance-free and is suitable for sensitive skin. It has a powerful blend of olive polyphenols that repair the skin and potent peptides that minimize the appearance of fine lines and wrinkles. Check out this review for a detailed understanding of this dermatologist-tested product.
Pros
- Soothes the skin
- Non-greasy
- Suitable for delicate skin
- Minimizes the appearance of fine lines
- Deeply nourishing
- Fragrance-free
- Hypoallergenic
- Dermatologist-tested
Cons
- Expensive
Pro Tip3. Best Exfoliating:Perricone MD No Rinse Intensive Pore Minimizing Toner
The No:Rinse Intensive Pore Minimizing Toner is packed with key ingredients like DMAE, salicylic acid, and a copper complex that gently exfoliate and rid the skin of residues. It dramatically minimizes the appearance of pores and leaves your skin looking refreshed, matte, and radiant. Not only does this keep pores clean and free of debris but the DMAE plumps the skin that surrounds the pores which helps to minimize the appearance of the opes and refines the texture. It has a lightweight consistency and is free from parabens, sulfates, and mineral oil.To find out more about Perricone MD No:Rinse Intensive Pore Minimizing Toner, check out this video review.
Hillary Clark, a Medical Esthetician, mentions, “Not only does this keep pores clean and free of debris but the DMAE plumps the skin that surrounds the pores which helps to minimize the appearance of the opes and refines the texture.”
Pros
- Minimizes the appearance of enlarged pores
- Improves skin texture
- Exfoliates the skin gently
- Mineral oil-free
- Matte finish
Cons
- Unpleasant fragrance
Why We Think It's Worth Buying
This product has received 984 reviews from customers on Amazon, indicating its popularity and reliability.
4. Best Lightweight:Perricone MD Cold Plasma Plus
No products found.
Perricone MD Cold Plasma Plus is a multitasking powerhouse that is packed with vitamin C ester that reduces the appearance of dark spots. Copper tripeptides improve skin elasticity, while omega 3,6, and 9 fatty acids promote smooth and supple skin. This lightweight and fragrance-free cream gets absorbed instantly into the skin. It reveals radiant skin by adding essential moisture to it.
Pros
- Makes skin look youthful
- Evens out the skin tone
- Reduces the appearance of fine lines and wrinkles
- Increases skin radiance
- Lightweight
- Fragrance-free
Cons
- Expensive
5. Best For Sagging Eyelids:Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum
No products found.
Perricone MD Essential Fx Acyl-Glutathione Eyelid Lift Serum has a revolutionary formula that contains a vitamin F blend to replenish the skin’s natural moisture barrier and reduce the appearance of creases along the upper eyelid. It is a lightweight serum that gets absorbed quickly and softens the appearance of dark circles and wrinkles.
Pros
- Lifts sagging eyelids
- Gets absorbed quickly
- Reduces the appearance of wrinkles
- Reduces under-eye circles
- Lightweight
- Paraben-free
- Sulfate-free
Cons
- Not suitable for all skin types
- Expensive
6. Best For Skin Tightening:Perricone MD Neuropeptide Night Cream
No products found.
This is Perricone MD’s most advanced night cream. It contains neuropeptides to address all types of wrinkles, amino acids to nourish the skin, and DMAE to visibly lift your skin. It has an ultra-rich and creamy formula and is a perfect addition to any skincare routine. Amazon reviews suggest that with regular usage, you can expect an overall improvement in skin tone and a visible increase in skin radiance.
Pros
- Strengthens the skin
- Tightens the skin instantly
- Imparts a radiant glow
- Improves skin tone and texture
- Mineral oil-free
- Vegan
Cons
- Expensive
7. Best Hydrating:Perricone MD Essential Fx Acyl-Glutathione Deep Crease Serum
No products found.
This is a highly potent serum that is designed to work on deep-set wrinkles, lines, creases, and deep forehead wrinkles. It is formulated with Acyl-Glutathione, which helps in protecting and replenishing the skin. A vitamin F blend restores soft and supple skin by improving the skin’s moisture barrier. It helps transform fragile skin into healthy-looking skin.
Pros
- Reduces deep-set wrinkles
- Offers intense hydration
- Tightens the skin
- Lightweight
- Paraben-free
Cons
- Strong fragrance
8. Best Satin Finish:Perricone MD Instant Blur Compact
No products found.
Perricone MD Instant Blur Compact is powered by skin-smoothing alpha-lipoic acid that blurs and minimizes the appearance of wrinkles, fine lines, and redness both instantly and over time. Hillary Clark loves this product and explains it as ‘the only primer and finishing product that contains skincare to calm inflammation.’ It is a complexion primer, so it can be used alone or as a makeup primer. It comes along with a compact mirror, so you can apply it anytime, anywhere.
Pros
- Satin finish
- Blurs imperfections
- Lightweight
- Can be used as a makeup primer
- Vegan
- Comes with a mirror
Cons
- Expensive
9. Best With SPF:Perricone MD Vitamin C Ester Photo Brightening Moisturizer Broad Spectrum SPF 30
No products found.
This is an oil-free, anti-aging moisturizer that contains powerful ingredients like vitamin C ester to brighten your skin. Alpha-lipoic acid reduces the appearance of fine lines and wrinkles, while titanium oxide and zinc oxide deliver SPF protection from harmful UVA and UVB rays. It works as a hydrating exfoliant that eliminates dead skin cells from the skin. It also reduces the appearance of deep wrinkles in the skin. Multiple consumer tests conducted revealed that it improved skin texture and made the skin look brighter.
Pros
- Broad spectrum SPF 30
- Reduces fine lines and wrinkles
- Brightens the skin
- Oil-free
- Lightweight
- Fragrance-free
Cons
- Expensive
10. Best For Instant Glow:Perricone MD No Makeup Blush
Perricone MD No Makeup Blush is a fragrance-free and lightweight gel-cream blush that tints your cheeks with a healthy and youthful flush of color. It contains skin-improving ingredients like vitamin C ester and Chinese ginger plant extract that naturally protect and brighten the skin. Hillary Clark says, “I use it on cheeks, lips, and above the crease to “wake up” a mature eye.”
Pros
- Imparts an instant glow
- Reduces dullness
- Fragrance-free
- Lightweight
- Paraben-free
- Vegan
Cons
- None
11. Best For All Skin Types:Perricone MD Vitamin C Ester Brightening Serum
No products found.
This serum is formulated with Dr. Perricone’s proprietary vitamin C ester to instantly boost your skin’s radiance and helps get a rejuvenated skin. It also evens out your skin tone and reduces the appearance of fine lines and wrinkles. It reduces skin redness, evens out uneven texture, and imparts a healthy glow to the skin. It is non-greasy and lightweight and has a powerful blend of ingredients that are suitable for all skin types.
Pros
- l Brightens the skin
- l Evens out the skin tone
- l Reduces the appearance of wrinkles
- l Lightweight
- l Suitable for all skin types
- l Paraben-free
- l Sulfate-free
Cons
- Expensive
12. Best Fragrance-Free:Perricone MD No Makeup Foundation Serum
No products found.
This skin-improving serum foundation is available in 8 shades. It has a semi-matte finish with buildable coverage. It contains powerful ingredients like neuropeptides to minimize the appearance of wrinkles, daisy flower extract to address uneven skin tone, bisabolol to brighten the skin, and broad spectrum SPF 20 to protect the skin. Hillary Clark shares her opinion about this product: “Think: skincare and makeup had a baby. The texture is divine and extremely flexible for mixing and layering. You can walk out of the house feeling confident in the way that your skin looks and know that it is protected.”
Pros
- Broad spectrum SPF 20
- Softens the skin
- Brightens the skin
- Lightweight
- Fragrance-free
- Vegan
Cons
- Slightly greasy
13. Best Quick-Absorbing:Perricone MD Vitamin C Ester Brightening Eye Serum
No products found.
Perricone MD Vitamin C Ester Brightening Eye Serum is a therapeutic treatment for the eye area. It minimizes the appearance of under-eye circles and discoloration and restores youthful-looking eyes. It is a lightweight and fast-absorbing eye serum that has powerful active ingredients. It promotes collagen protein production which is the natural building block to boost skin elasticity and maintain the skin’s youthful appearance. It provides a dewy glow to the skin.
Pros
- Lightens dark circles
- Improves skin firmness
- Non-irritating
- Gets absorbed quickly
- Vegan
- Paraben-free
Cons
- Expensive
14. Best For Overall Health:Perricone MD Super Greens Supplement Powder
No products found.
Perricone MD Super Greens is a superfood supplement powder that gives you a daily boost of nutrition to fight free radical damage and promote overall well-being. It contains powerful ingredients like the Nrf2 Antioxidant Support Complex, a greens blend of 11 vegetables, B vitamins, and probiotics that offer antioxidant benefits to the skin. It is available in single-serve packets, making them convenient to take on the go. According to multiple reviewers on Amazon, this product delivers quick results while tasting absolutely delicious.
Pros
- Promotes healthy skin
- Supports digestive health
- Nourishes the body
- Great taste
- Soy-free
- Fish-free
- Nut-free
Cons
- None
15. Best Crease-Proof:Perricone MD No Makeup Eyeshadow
No products found.
Perricone MD No Makeup Eye Shadow is formulated with Acyl-Glutathione which instantly brightens and awakens the eyes to give you a youthful and natural look. It is a lightweight liquid formula with light-reflecting pigments that leave a soft satin finish with a pearlized or iridescent effect on the skin. It can be worn alone or under makeup as a brightening primer for smoother and more even-toned eyelids.
Pros
- Evens out the skin tone
- Crease-proof
- Satin finish
- Fragrance-free
- Long-lasting
Cons
- None
Perricone MD products are a favorite among users for the brand transparency and the evidence-based formulas. The brand offers several different formulations for various skin types and concerns, and choosing one for your needs may be confusing. Given below is a list of factors to keep in mind while you choose the best Perricone MD products for use.
What To Look For In The Best Perricone MD Product
- Ingredients
Look for the main Perricone MD ingredients, including hyaluronic acid, DMAE, phytocannabinoids, vitamin C ester, vitamin E, and neuropeptides in the products you choose. These ingredients are dermatologically proven to visibly reduce skin issues like darsk spots and blemishes, wrinkles and fine lines, and also increase the hydration levels of the skin.
- Formulation
Some Perricone MD products are scented, and while it may be enticing to some, the perfume may be too harsh on the pores and skin. In such cases, opt for fragrance-free products of the brand.
Choose lightweight products that easily penetrate your pores and skin and do not leave any oiliness. Perricone MD products are usually easy to blend into the skin and do not cause any sweating or clogging of pores.
- Age
Perricone MD skin care line has separate products for different skin types and skin concerns. For mature skin types, choose products that combat wrinkles, dark spots, fine lines, or blemishes. Look for products containing substances like hyaluronic acid, DMAE, phytocannabinoids, and other hydration and collagen-boosting ingredients.
- Skin Type
Look for the products which are suitable for your skin type. For oily skin, look for non-greasy, lightweight formulas. For dry skin, choose creamy formulas that offer long-lasting moisturization. Even though most Perricone MD products are safe for all, it is best to begin with a patch test.
Infographics: Amazing Facts About Perricone MD Products
Perricone MD offers a diverse range of products targeting various skin concerns. With a focus on effectiveness, its skin care solutions have gained global recognition. The brand’s reputation rests on its commitment to quality and innovation, making it a go-to choice for beauty enthusiasts. Learn more in the infographic below.
Illustration: StyleCraze Design Team
The Bottom Line
Aging is an inevitable skin concern, especially when you are nearing your mid-twenties. What you need to fight skin aging are the holistic skin care products of Perricone MD. The brand’s core belief is to provide beauty from within. From supplement powders to moisturizers, the brand provides all kinds of products. The products listed in our article soothe your skin, combat aging signs, improve skin texture, and promote healthy skin. If you are looking for a vegan moisturizer with anti-aging benefits, try the Perricone MD High Potency Classics: Face Finishing & Firming Moisturizer. However, day creams are not the same as night creams. To take care of the skin at night. try the Perricone MD Neuropeptide Night Cream which contains neuropeptides to nourish the skin and give you a radiant glow. Further, a fragrance-free, lightweight blush that combats dullness would be the Perricone MD No Makeup Blush. However, do cross-check the ingredients list to ensure that you are not allergic to any of the ingredients used in the product.
Frequently Asked Questions
How long does it take for Perricone MD to work?
The Perricone MD products show significant results within three to eight weeks of usage, depending on the product type.
Does Perricone work on the neck?
Yes. The Perricone MD Neuropeptide Night Cream works effectively on the neck area by improving skin elasticity.
Can I use cold plasma sub D on my face?
Yes. The Perricone, MD Cold Plasma Plus is the right choice to improve your skin elasticity and offer you rejuvenated skin overnight with regular usage.
Why Trust StyleCraze?
The author of this article, Shiboli Chakraborti, is a certified skin care coach and passionate about providing comprehensive articles to her readers. She believes that the best Perricone MD products are reliable for the skin. So, she conducted in-depth research by analyzing the product specifications and user reviews before presenting this comprehensive list. These products make your skin firmer, minimize the appearance of fine lines, improve skin texture, and enhance the radiant glow of your skin.
Read full bio of Hillary Clark
Read full bio of Shiboli Chakraborti
Read full bio of Aditi Naskar
Read full bio of Ramona Sinha
Community Experiences
Join the conversation and become a part of our empowering community! Share your stories, experiences, and insights to connect with other beauty, lifestyle, and health enthusiasts.