10 Best Dermatologist-Approved Cystic Acne Treatments Of 2025
Unveil clear and flawless skin with products that work like a charm on cystic acne.
Dr. Bita Farrell is a board-certified anesthesiologist and the founder of Natural Aesthetics Center (NAC), a medical spa in Westlake Village, California. She has over 20 years of experience in the medical field and specializes in injectables, such as Botox and fillers, in addition to nonsurgical, minimally invasive skin tightening devices for facial rejuvenation.
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Experience: 4 yearsShiboli has a master’s degree in English literature from The English and Foreign Languages University, Hyderabad, and is a certified skincare coach with four years of experience. As a commerce editor, she guides her team members on the best practices to create crisp and authentic content.
Read full bio of Shiboli Chakraborti
Experience: 3 yearsKrati is an associate commerce editor, a certified skin care coach, and a beauty enthusiast. She has a master’s degree in advertising and publishing relations from DAVV University and three years of experience in writing and editing for different niches.
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Experience: 5 yearsMedha Deb is a commerce editor with a master's degree in applied linguistics from the University of Hyderabad, which has allowed her to develop a deep understanding of language and its application in various contexts. She specializes in the areas of beauty, health, and wellness and is committed to ensuring that the content on the website is of the highest quality.
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Cystic acne is the most painful and pus-filled acne that usually occurs with clogged pores. It affects the deeper skin layers and is tough to treat. But the best cystic acne treatments can come in handy if you want to try some OTC treatments at home before going to a dermatologist.
Cystic acne can also spread if it pops. It is the most severe form among all the hormonal acne types. But it can be difficult to find the best product to remedy cystic acne. So, for your convenience, we have put together a list of the 10 best products that you can use to treat cystic acne. Check them out below!
In This Article
Top 10 Cystic Acne Treatments That Work Like A Charm
1. Avarelle ZITOUT® Original Acne Cover Patch
The Avarelle Acne Patch is made with hydrocolloid dressing, tea tree, and calendula oils that are extremely gentle on your skin and help to extract the gunk and clear zits. It contains Centella Asiatica (often referred to as Cica), a powerhouse of antioxidants that promotes faster healing of this hormonal acne. These clinically-backed topical therapy skincare patches come in different sizes and blend well with all skin tones. To make an informed decision before buying, you can check out this review video, which showcases the reviewer’s experience.
Pros
- Available in different sizes
- Easy-peel design
- Dust-free
- Re-sealable packaging
- Hydrocolloid technology
- Drug-free
- Sticks well
- Works on all skin types
- Clinically-tested
Cons
- May not work on severe cystic acne.
Quick Tip
Why We Think It's Worth Buying
This product is so liked by shoppers that it has gained over 10,352 great reviews on Amazon.
2. Differin Gel Adapalene Gel 0.1% Acne Treatment
Dermatologists often prescribe retinoids for treating acne. If you want to try a similar OTC formulation, check out the Differin Gel. It contains 0.1% adapalene, a retinoid-like compound that has similar effects. This professional-grade gel treatment for acne reduces inflammation, revitalizes complexion, cleanses the skin pores, and restores the skin texture. You have to use it as a spot treatment in your morning or evening skin care routine, and it has clinically proven results in combating acne.
Pros
- FDA approved
- Developed by dermatologists
- Alcohol-free
- Fragrance-free
- Oil-free
- Water-based formula
- Non-comedogenic
- Minimizes acne scarring
- Reduces hyperpigmentation
Cons
- None
ProTipWhy We Think It's Worth Buying
This product has received 5,370 reviews from customers on Amazon, indicating its popularity and reliability.
3. Cetaphil Daily Facial Cleanser
When you have cystic acne, you need to go easy on the facial cleanser and use a mild formula for hormonal acne. The Cetaphil Daily Facial Cleanser cleanses your skin thoroughly without drying it. It is a low-lather formula that does not damage the natural moisture shield of your skin. This clinically proven product is suitable for normal, oily, and sensitive skin types and it has received positive reviews from users.
Pros
- Dermatologist-recommended
- Hypoallergenic
- Clinically-proven
- Aluminum-free
- Non-comedogenic
- Mild
- Non-irritating
Cons
- Some users may not like the fragrance.
Why We Think It's Worth Buying
It has received 1,865 reviews on Amazon and is a popular choice among shoppers.
| Avarelle Acne Cover Patch | Differin Gel Adapalene Gel 0.1% Acne Treatment | Cetaphil Daily Facial Cleanser | |
|---|---|---|---|
| Skin Type | All | Sensitive | Oily,sensitive |
| Dimensions | 0.04 x 3.54 x 6.65 inches | 1.5 x 2.1 x 6.5 inches | 7.5 x 4.3 x 4.1 inches |
| Weight | 0.48 Ounces | 0.48 Ounces | 2.4 Pounds |
| Rating | |||
| Reviews | 10,352 | 5,370 | 1,865 |
| Price | $8.49 | $13.79 | $22.88 |
4. Acne Free Oil-Free Acne Cleanser
The Acne-Free Oil-Free Cleanser contains 2.5% advanced micronized benzoyl peroxide – an effective anti-acne standout ingredient that helps enhance skin clarity. It clears breakouts, and prevents different types of hormonal acne, like blackheads, whiteheads, pimples, and cystic acne. It contains ceramides that soothe inflammation and promote healing. The ceramides also help maintain the natural moisture barrier of the skin and keep your dehydrated skin moist.
Pros
- Safe for face and body acne
- Dermatologist recommended
- Fragrance-free
- Reduce blemishes
Cons
- May dry out sensitive skin.
ProTipWhy We Think It's Worth Buying
With over 878 Amazon acclaimed reviews, this product is sure to find a place in everyone’s shopping bag.
5. Differin Daily Deep Cleanser
The Differin Daily Deep Cleanser is for those with sensitive skin. It contains 5% benzoyl peroxide which has antibacterial properties and helps cleanse the skin thoroughly, reduces excess oil, and prevents further inflammation through bacterial resistance. It is less abrasive on your face and reduces skin redness and irritation.
Pros
- Paraben-free
- No harsh chemicals
- Hydrating
- Dermatologist-tested
Cons
- Might not suit dry skin.
Why We Think It's Worth Buying
More than 19,629 rave reviews on Amazon prove why we are so in awe of this product.
6. La Roche-Posay Effaclar Duo Acne Treatment
If you want visible, long-lasting results, this product claims to give it in just three days. The La Roche-Posay Effaclar Duo Acne Treatment is a widely used OTC product for acne control. This clinically backed skincare has an oil-free formula that contains micro-exfoliating LHA (Lipo-Hydroxy Acid) and antibiotic medication benzoyl peroxide that go deep inside the skin pores and clear blackheads and whiteheads. This dermatologist-tested formula is suitable for all skin types, including sensitive skin.
Pros
- Dermatologist tested
- Suitable for sensitive skin
- Non-drying
- Fast absorbing
- Oil-free
- Paraben-free
Cons
- Might cause mild irritation.
7. Proactiv Emergency Blemish Relief
This is an extremely effective spot treatment that targets deep-rooted acne. The Proactive Emergency Blemish Relief contains prescription-grade (5%) micro-crystal benzoyl peroxide. You have to apply a thin layer of the product to the affected area. It helps to absorb excess oil, clean the skin pore, reduce acne inflammation, and prevent blemishes. Click here to check out this YouTuber’s unbiased review.
Pros
- Dermatologist tested
- Non-comedogenic
Cons
- Not suitable for sensitive skin
- Expensive for the quantity
8. PanOxyl Acne Creamy Wash
The active ingredient of this product is 4% benzoyl peroxide. It contains three emollients and four humectants to balance out the drying nature of the antibiotic benzoyl peroxide. The PanOxyl Acne Creamy Wash is gentle yet powerful that clears up existing moderate acne quickly, regulates sebum production, and prevents new blemishes. It helps your skin shed dead cells and prevent clogging the pores.
Pros
- pH-balanced
- Non-irritating
- Non-drying
Cons
- Might not suit sensitive skin.
9. KILLA Kit by ZitSticka
This acne patch is unlike other hydrocolloid patches. The Killa Kit is meant for acne in its early stages. This dermatologically-approved hydrocolloid patch has a Microdart delivery system that helps deliver the ingredients to the zit to stop its progress. It contains salicylic acid, a potent acne-fighting ingredient, along with niacinamide, hyaluronic acid, and oligopeptide-76. It is a safe and effective treatment for acne and pimples, and contains ingredients that calm the zit and aid skin healing. Here’s a personal review video to help you get a better understanding of the product.
Pros
- Vegan
- Cruelty-free
- Dermatologist-backed
Cons
- Expensive
10. Glytone Acne Treatment Spray
Got acne on your back and shoulders? This ingredient-driven acne treatment spray by Glyton can help. This topical formulation contains salicylic acid that helps unclog pores, and dissolve dirt and oil, along with benzoyl peroxide to fight the acne-causing bacteria and sulfur to absorb excess oil and clear the breakouts.
Pros
- Fragrance-free
- Non-comedogenic
- Oil-free
Cons
- Expensive
Infographic: Key Ingredients In Products For Cystic Acne Treatment
Cystic acne can be painful and annoying. But the good news is these OTC products can help provide some relief at home. They contain ingredients that help eliminate acne-causing bacteria, exfoliate dirt, remove excess oil, and support the growth of new skin cells. Scroll down and check out this infographic for the key ingredients found in these cystic acne treatments. Illustration: StyleCraze Design Team
The Bottom Line
Cystic acne is painful, and it can be quite a challenge. Before going to the dermatologist, you can try some OTC products to treat cystic acne at home. The Differin Gel Adapalene Gel 0.1% Acne Treatment is an alcohol-free formula that helps reduce inflammatory acne, while the Cetaphil Daily Facial Cleanser thoroughly cleanses the skin without drying it. The Acne Free Oil-Free Acne Cleanser is also a good pick for it soothes inflammation and promotes healing. Depending on the severity of your acne breakouts, you need to choose a product that suits your requirements. The reviewed options in the curated list have a dermatologist-developed and hypoallergenic formula devoid of synthetic toxins. Based on your preference and reviewer feedback, you will find a pick from facial cleansers and sprays to acne patches. Besides ointments and other medications, you can use these products as a treatment for acne to see the best results.
Frequently Asked Questions
Does cystic acne go away?
Cystic acne improves with proper treatment. You need to consult a doctor and follow the medications to get clear skin.
Which acid is the best for cystic acne?
Azelaic acid or salicylic acid is the best to get rid of cystic acne. They reduce dead skin cells and kill bad bacteria that cause acne.
Should I moisturize if I have cystic acne?
Yes, make sure to moisturize your skin if you have cystic acne. Moisturizing helps keep the skin soft and supple, maintains a healthy skin barrier, and improves overall skin health.
Should I exfoliate if I have cystic acne?
Yes, gently exfoliate your skin to get rid of excess sebum and dead skin cells. Do not use rough exfoliators that can further accelerate the condition or cause excess redness and inflammation.
Is ice or heat better for cystic acne?
Both ice and heat may work wonders on cystic acne. Ice reduces the swelling while heat helps the pimples heal more quicker.
What should you not do with cystic acne?
Do not scrub your skin with rough products that may cause more irritation. Do not touch the cysts unnecessarily or pick at the blemishes.
Is retinol or benzoyl peroxide better for cystic acne?
Retinol is better than benzoyl peroxide when it comes to cystic acne. Retinol reduces inflammation, clears away bad bacteria, and minimizes pores and bumps.
Why Trust StyleCraze?
The author, Shiboli Chakraborti, is a certified skin care coach and understands the hardships cystic acne can pose. She has compiled this list of the best cystic acne treatment products following extensive research of the treatment options available and an in-depth analysis of the reviews posted by users on multiple online forums. These mild over-the-counter products have non-irritating and non-comedogenic formulas.
Read full bio of Dr. Bita Farrell
Read full bio of Shiboli Chakraborti
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Read full bio of Medha Deb
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